![]() Since then, however, progress has been stalled by drug delivery issues - how do you transport the fragile RNA to the target cells?Īlnylam ( ALNY), a direct rival of Arrowhead in the RNAi space, has commercialised five RNAi drugs, often in collaboration with larger pharmas, including ONPATTRO, GIVLAARI and OXLUMO, indicated for hATTR Amyloidosis, Acute Hepatic Porphyria, and Primary Hyperoxaluria respectively, and earning revenues of $475m, $128m, and $60m respectively in 2021, which represents 83% year-on-year growth.Īnother of Arrowhead's rivals, Dicerna, was acquired last year by Novo Nordisk ( NVO) in a deal worth $38.25 per share, or ~$3.3bn, even though the company had failed to commercialise any drug candidates, and its best candidate, Nedosiran, had failed to outperform Alnylam's Oxlumo in a late-stage Primary Hyperoxaluria trial immediately prior to the acquisition. RNAi therapeutics has been around for a while - scientists Craig Mello and Andrew Fire received a Nobel Prize for their work on RNAi in 2006, demonstrating the process of gene silencing using double-stranded RNA. Post navigation ← Alpha 13.3 Patch Oh Yeah! Alpha 13.GoShiva/iStock via Getty Images Investment ThesisĪrrowhead Pharmaceuticals ( NASDAQ: ARWR) refers to itself as a "mid-cap RNAi therapeutics platform company with a broad pipeline of wholly-owned and partnered product candidates," and it has tended to be strongly favored by investors who believe the biotech can become a leader in the RNA-interference field, and eventually make a difference in lucrative rare and mainstream disease markets.Īlthough Arrowhead is yet to commercialise a drug candidate many people believe that its Targeted RNAi Molecule, or "TRiM" platform is the most effective at generating plausible drug candidates to "silence" or disrupt mutated genes that are responsible for diseases of the liver, lung, tumor and muscle. This entry was posted in News on by rhuenink. Fixed: Weights of casings, bullet tips and buckshot so it can’t be scrapped for infinite ammo resources.Fixed: Raised MaxVoices on rapid fire weapons to fix them from getting cut off.Fixed: Mining helmet now has a range of attributes based on quality.Fixed: Various blocks that couldn’t be repaired.Fixed: Skills can be purchased with LMB + RMB, allowing you to spend extra points.Fixed: Improvement for high memory consumption in dedicated servers: pools are cleared when all players left a server.Fixed: Loot containers are empty at some levels of scavenging.Fixed: Special ö opens up console when used in chat.Fixed: Show “distance to friend” in score board instead of “walked distance”.Fixed: Player loses ownership over his land claim blocks.Fixed: Gun repair equalizes part quality.Fixed: MaxVoices on footsteps set to 2 so a footstep doesn’t have to finish playing before allowing another.Fixed: Forge now plays the ambient fire audio again.Changed: Entity spawning definition now support day ranges.Changed: Glass only takes 10 units of glass and 1 clay instead of 100 and 10.Changed: Everything smelts twice as fast in the forge.They take much less iron than before, but are not near as durable. Changed: Rebar frames are now made in the forge and require an anvil.Changed: Doubled the resource requirements for bricks.Changed: Various recipe requirements to be more consistent.Changed: Cobblestone now takes 5 cobblestones to repair. ![]() Changed: OnPress is only fired by left mouse button throughout XUI.Changed: Crossbow bolts now assigned to archery and weapons skills.Changed: Increased repair amount on forged iron and repair kits.Changed: Chainsaws now use chainsaw parts instead of auger parts to assemble.Changed: Hover color for skill rows to match all other list hovers.Added new spawning definitions to summoned hordes day 28-60, 61-90 and 90 to infinity.Added: More gas to complete cars, partially damaged cars have a lower chance to find gas and in lower quantity.Added: Forge recipes for scrap iron, brass, lead, small stone, clay lumps and broken glass so the user can quickly get his materials out of the forge.Added: Button XUI view component that handles hover/selection for clickable icons.We are optimistic about our early reports of better performance, less memory and smoother play but longer testing is needed. Note this patch should be compatible with your A13, A13.1, A13.2 and A13.3 saved games. We have a new patch ready for survival consumption.
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